On May 29, 2026, a research team led by Dr. Li Yanxin from the Institute of Basic Medical Sciences (IBMS), Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), in collaboration with Dr. Jiao Jianwei from the Institute of Zoology, Chinese Academy of Sciences (CAS) and others, published an important study titled "Decoding the spatiotemporal development of human meninges" in Cell. This study reveals a groundbreaking spatiotemporal framework of human meningeal development, the functional differences among distinct meningeal layers, and the key mechanisms by which meningeal immunity influences brain development. It provides new insights into meningeal developmental biology and meningeal-brain interactions, and offers an important theoretical basis and potential targets for the diagnosis and treatment of meningeal-related diseases. The meninges are not merely a "protective sheath" enveloping the brain, but rather a dynamic microenvironment involved in...

On June 9, 2026, the research team led by Professor Wang Jing from the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, published a paper inCirculationtitled "Alternative splicing of TPM1 mediated by SRPK3 drives cardiac diastolic dysfunction in heart failure with preserved ejection fraction." The study reports that alternative splicing of TPM1 exon 9a is a key pathogenic mechanism underlying myofilament disarray and diastolic dysfunction in HFpEF, and this process depends on the upstream splicing kinase SRPK3. SRPK3 may represent a novel therapeutic target for HFpEF. Heart failure is the end-stage manifestation of various cardiac diseases, and its morbidity and mortality remain persistently high. Among these, heart failure with preserved ejection fraction accounts for approximately 50% of all heart failure cases. The pathological mechanisms of HFpEF are complex, and existing therapeutic strategies for heart failure with reduced ejection fraction (HFrE...

On March 13, 2026, Bo Huang's team at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, published a research article entitled "IDO1 regulating ROS rhythm reveals glycogenolysis/PPP as a cancer treatment target" in Nature Chemical Biology. The study identifies the canonical immune-checkpoint molecule indoleamine 2,3-dioxygenase 1 (IDO1) as a key regulator of reactive oxygen species (ROS) rhythmicity in tumor cells. It further elucidates a compensatory mechanism established by human tumor cells in response to hypoxia-induced disruption of ROS rhythms and proposes that dual inhibition of IDO1 and the aryl hydrocarbon receptor (AhR) can effectively overcome therapeutic resistance, providing a new translational strategy for cancer treatment. Energy conversion is fundamental to cellular life, yet the generation of ATP inevitably produces harmful reactive oxygen species (ROS). ATP production is one side of the coin; controlling ROS so that it shifts from a...

A new clinical study published inBloodwas led by Prof. Jianxiang Wang, Hui Wei, and YingchangMi from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College. The results demonstrated that venetoclax combined with pediatric-inspired chemotherapy yields significant efficacy in newly diagnosed adolescent and adult patients with Philadelphia-negative acute lymphoblastic leukemia (Ph-negative ALL). It is the first large-scale prospective cohort study of its kind. These findings provide important evidence for optimizing current treatment strategies for Ph-negative ALL. Acute lymphoblastic leukemia (ALL) is a highly aggressive hematologic malignancy. Although breakthrough has been made in the treatment of pediatric patients over the past few decades, outcomes for adolescent and adult patients remain suboptimal. In recent years, pediatric-inspired chemotherapy regimens have become the standard care for adolescents an...

A new study, led by Prof. Yu Lan from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, in collaboration with Prof. Zhenyu Xiao from Beijing Institute of Technology and Prof. Bing Liu from the Chinese PLA General Hospital, and published in Nature, provides new insights into the emergence of the first blood cells during early human development, revealing that human primitive hematopoiesisinitiates prior to gastrulation and has a hypoblast origin,and that the early yolk sac contains differentregions that support the generation of distinctblood lineages. Gastrulation is a pivotal stage of embryonic development during which the embryo transforms from a simple two-layered structure into a complex three-layered architecturethat later give rise to diverse tissues and organs. Blood cells are among the earliest cell types to emerge, and they have traditionally been thought to originate from the epiblast-derived...

Classical BCR::ABL1-negative myeloproliferative neoplasms (MPNs) are a group of hematologic malignancies characterized by the clonal expansion of hematopoietic stem and progenitor cells. These diseases are driven predominantly by JAK2V617F and mutations in CALR or MPL [1]. In addition to elevated blood cell counts and an increased risk of thrombosis, patients with MPNs commonly exhibit chronic inflammation and immune dysregulation. Immune abnormalities are particularly pronounced in patients harboring the JAK2V617F mutation [2,3]; however, the underlying immunoregulatory mechanisms have yet to be systematically elucidated. On January 6, 2026, a collaborative research team led by Dr. Lei Zhang and Dr. Rongfeng Fu from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, published a research article online in Drug Resistance Updates (IF: 21.7). The article was entitled “IFNα2b modulates anti-tumor immune respo...