王璐璐，1973年出生，籍贯杭州。医药生物技术研究所研究员，博士生导师。1992年考入上海医科大学药学专业，1996年获学士学位。1999年在中国协和医科大学药剂学专业攻读硕士学位，从事药物靶向递送研究。2014年在北京协和医学院药理学专业攻读博士学位，从事小分子药物机制研究。1996年进入医药生物技术研究所工作，1998年调入药物研究所，2004年任助理研究员，2012年任副研究员，2021年任研究员。2022年调回医药生物技术研究所，从事纳米生物技术研究。

长期从事纳米药物设计及作用机制研究。工作聚焦药物的转化性，通过生物学与药学的结合促进新药研究的深度、创新性及实用性。重点为抗代谢及抗肿瘤药物研发。 主要工作之一为小檗碱及其衍生物的基础与转化研究，形成了从药理机制解析—递送系统构建—临床转化的全程创新能力，作为核心骨干推动小檗碱制剂研发并获临床批件（CHXL1500649），推动小檗碱衍生物HTD1801进入降糖Ⅲ期临床（CHXB2400062）。

1. Kaichao Song i#, Ling Ren i#, Xiuping Guo i#, Gang Ren i#, Yanan Sun, XiaoLian Tian, Chujuan Hu, Mingyu Pan, Quanyong Yu, Zhigang Luo, Yumei Hao, Peng Lei, Haoyang Yu, Sitong Yang, Qingbo Chen, Yuanbin Li, Shan Wang, Yingying He, Zhouguang Hui*, Wensheng Zheng*, Jiandong Jiang*, Lulu Wang*. Microbiotaresponsive oral nanoamifostine enables colorectalspecifc radioprotection and tumor immunity via gut microenvironment reprogramming. Advanced Composites and Hybrid Materials (2025) 8:432. (IF=21.8)

2. Yiyang Chen, Shuang Liang, Yuxuan Peng, Kongshuo Ma, Kaiqing Yun, Xinbo Ma , Linna Hai, Lin Mei*, Lulu Wang*, Zhaohui Wang*. Nanomaterials-enabled mRNA delivery for Cancer immunotherapy. Coordination Chemistry Reviews 543 (2025) 216945. (IF=23.5)

3. Xia Niu i#, Ge Chang i#, Ning Xu i#, Rui Li i#, Bingyu Niu, Rui Mao, Shan Wang, Guiling Li*, Jiandong Jiang*, and Lulu Wang*. Vitamin AIntegrated Cinnamaldehyde Nanoemulsion: A Nanotherapeutic Approach To Counteract Liver Fibrosis via Gut−Liver Axis Modulation. ACS Nano 2025 19(10), 10433-10451. (IF=17.6)

4. Chuchu Zhou, Rou Tang, Huajin Tan, Yige Yang, Peipei Meng, He Li, Kaichao Song, Xiaochuan Tan , Xiuping Guo, Ling Ren, Shuwang He, Ya Meng, Yumei Hao, Mingbao Lin, Yujia Zhang, Hongdong Huang*, Lulu Wang*, Wensheng Zheng*. Biomimetic Nanodisks Are Effective Against Tubulointerstitial Fibrosis via Targeting Interstitial Microenvironment. Circulation Research. 2024;135:e150. (IF=16.5)

5. Xia Niu#, Yanan Meng#, Jinjin Cui#, Rui Li, Xiao Ding, Bingyu Niu, Ge Chang, Ning Xu, Guiling Li*, Yucheng Wang*, and Lulu Wang*. Hepatic Stellate Cell- and Liver MicrobiomeSpeciffc Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis ACS Nano 2023 17 (23), 23608-23625. (IF=15.8)

6. 1. Jin-Jin Cui#, Rui Li#, Xiao-Lei Ma#, Hao-Yang Yu#, Zhi-Gang Luo#, Peng Du, Ling Ren, Xiao Ding, Xiu-Ping Guo, Wen-Sheng Zheng, Jian-Dong Jiang,* Yongsheng Che,* and Lu-Lu Wang*. Prebiotic-Based Nanoamorphous Atorvastatin Attenuates Nonalcoholic Fatty Liver Disease by Retrieving Gut and Liver Health. Small Struct 2023, 4(8):2200312. (IF=13.9)

7. Ling Ren#, Xiao-Lei Ma#, Hong-Liang Wang#, Rui Li#, Jin-Jin Cui, Peng-Ju Yan, Ya-Nan Wang, Xiao-You Yu, Peng Du, Hao-Yang Yu, Hui-Hui Guo, Rou Tang, Yong-sheng Che, Wen-Sheng Zheng*, Jian-Dong Jiang*, Lu-Lu Wang*. Prebiotic-like cyclodextrin assisted silybin on NAFLD through restoring liver and gut homeostasis. J Control Release. 2022, 348:825–840. (IF=10.5)

8. Xiao-Lin Li#, Jin-Jin Cui#, Wen-Sheng Zheng#, Jin-Lan Zhang#, Rui Li, Xiao-Lei Ma, Miao Lin, Hui-Hui Guo, Cong Li, Xiao-You Yu, Peng Du, Li-Min Zhao, Shuwang He, Pei Lan, Jian-Dong Jiang,* Yongsheng Che,* and Lu-Lu Wang*. Bicyclol Alleviates Atherosclerosis by Manipulating Gut Microbiota. Small. 2022, 18(9):2105021. (IF=13.3)

9. Yumei Hao#, Kaichao Song#, Xiaochuan Tan#, Ling Ren, Xiuping Guo, Chuchu Zhou, He Li, Jin Wen, Ya Meng, Mingbao Lin, Yujia Zhang,* Hongdong Huang,* Lulu Wang,* and Wensheng Zheng*. Reactive Oxygen Species-Responsive Polypeptide Drug Delivery System Targeted Activated Hepatic Stellate Cells to Ameliorate Liver Fibrosis. ACS Nano 2022, 16(12):20739−20757. (IF=17.1)

10. Jin-Lan Zhang#, Yu-Huan Li#, Lu-Lu Wang#, Hong-Qi Liu#, Shuai-Yao Lu#, Yong Liu, Ke Li, Bin Liu, Su-Yun Li, Feng-Min Shao, Kun Wang, Ning Sheng, Rui Li, Jin-Jin Cui, Pei-Chun Sun, Chun-Xia Ma, Bo Zhu, Zhe Wang, Yuan-Hao Wan, Shi-Shan Yu, Yongsheng Che, Chao-Yang Wang, Chen Wang, Qiangqian Zhang, Li-Min Zhao, Xiao-Zhong Peng*, Zhenshun Cheng*, Jun-Biao Chang*, Jian-Dong Jiang*. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduct Tar 2021, 6:414. (IF=38.1)