石杨，研究员、助理教授、博士/硕士导师，美国华盛顿圣路易斯大学博士、博士后。长期深耕阿尔兹海默症研究，研究发表在Nature, Neuron, JEM等期刊，多篇ESI高被引、F1000推荐论文，总引用4700余次。获得美国 Rainwater 基金会tau研究领导力奖；美国神经化学学会Marian Kies奖；华盛顿大学生物医学研究奖、神经系Tom Thach奖等学术奖项。回国后获得国家自然科学基金优秀青年科学基金项目（海外）项目资助，获得“北京市优秀青年人才”称号。

长期从事APOE-脂质代谢-免疫轴调控AD发病机制与创新疗法的研究。发现AD最大风险基因APOE对tau病理生成及tau介导的神经退行的直接调控作用 ；发现小胶质细胞是驱动tau病理生成及神经退行的根本动力；而APOE通过调节小胶代谢调控其激活，进而调控AD疾病进展。研究重新定义了AD发生发展的机制及APOE对AD的调控机制，推动APOE介导的脂质代谢及神经免疫成为AD机制研究与靶向治疗的新焦点。

1. Yang Shi#, Prabhakar Sairam Andhey, Christina Ising, Kairuo Wang, Lisa L Snipes, Kevin Boyer, Stephanie Lawson, Kaoru Yamada, Wei Qin, Melissa Manis, Javier Remolina Serrano, Bruno A Benitez, Robert E Schmidt, Maxim Artyomov, Jason D Ulrich, David M Holtzman*. Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms. Neuron 109 (15): 2413-2426. (IF=15.4, F1000, C100)

2. Yang Shi#, Melissa Manis, Justin Long, Kairuo Wang, Patrick M Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M Holtzman*. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. J Exp Med 216 (11): 2546-2561. (IF=10.6, ESI, C100)

3. Yang Shi# & David M Holtzman*. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nat Rev Immunol 18(12):759-772. (IF=60.9, ESI, C100)

4. Yang Shi#, Kaoru Yamada, Shane Antony Liddelow, Scott T Smith, Lingzhi Zhao, Wenjie Luo, Richard M Tsai, Salvatore Spina, Lea T Grinberg , Julio C Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M Sullivan, Caroline Baufeld, Michael W Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L Del-Aguila, John C Morris, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Anne M Fagan, Bruce L Miller, Adam L Boxer, William W Seeley , Oleg Butovsky , Ben A Barres, Steven M Paul, David M Holtzman*. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature 549(7673):523-527 (IF=48.5, F1000, ESI, C100)