王利，1982年生，籍贯湖北，中国医学科学院阜外医院研究员，博士生导师，心血管疾病国家重点实验室常务副主任。1999年考入武汉大学临床医学专业，2004年获得学士学位。2005年在北京大学生理学专业攻读博士学位，从事心血管发育与疾病相关研究。2010年进入斯坦福大学进行博士后研究工作，2011年进入美国国立卫生研究院进行博士后研究工作，主要从事心血管疾病的机制研究、以及诱导多能干细胞向心血管系统定向分化从而进行心血管再生医学的探索研究。2015年作为高层次海外引进人才全职归国，加入到中国医学科学院阜外医院心血管疾病国家重点实验室，任独立研究员，博士生导师，协和学者特聘教授。

心脏修复与再生，主要利用高通量组学手段研究心血管发育、疾病与再生的分子机制并寻找干预靶点的相关研究。

1. Li Z#, Yao F#, Yu P, Li D, Zhang M, Mao L, Shen X, Ren Z, Wang L*, Zhou B*. Postnatal State Transition of Cardiomyocyte as a Primary Step in Heart Maturation. Protein Cell. 2022 Nov;13(11):842-862. (IF=14.9)

2. Chen Y#, Zhang T#, Yao F#, Gao X, Li D, Fu S, Mao L, Liu F, Zhang X, Xu Y, Deng J, Li W, Fan G, Xiao C, Chen Y, Wang L*, Guo W*, Zhou B*. Dysregulation of Interaction Between LOXhigh Fibroblast and Smooth Muscle Cells Contributes to the Pathogenesis of Aortic Dissection. Theranostics. 2022 Jan 1;12(2):910-928. (IF=11.6)

3. Ren Z#, Yu P#, Li D, Li Z, Liao Y, Wang Y, Zhou B, Wang L*. Single-Cell Reconstruction of Progression Trajectory Reveals Intervention Principles in Pathological Cardiac Hypertrophy. Circulation. 2020 May 26;141(21):1704-1719. (IF=29.69)

4. Wang Y#, Yao F#, Wang L, Li Z, Ren Z, Li D, Zhang M, Han L, Wang SQ, Zhou B, Wang L*. Single-cell Analysis of Murine Fibroblasts Identifies Neonatal to Adult Switching that Regulates Cardiomyocyte Maturation. Nat Commun. 2020 May 22;11(1):2585. (IF=14.92)

5. Wang L#*, Yu P#, Zhou B#, Song J#, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S*. Single-cell Reconstruction of the Adult Human Heart During Heart Failure and Recovery Reveals the Cellular Landscape Underlying Cardiac Function. Nat Cell Biol. 2020 Jan;22(1):108-119. (IF=28.82, C100, ESI)

6. Yao F#, Yu P#, Li Y#, Yuan X, Li Z, Zhang T, Liu F, Wang Y, Wang Y, Li D, Ma B, Shu C, Kong W, Zhou B, Wang L*. Histone Variant H2A.Z Is Required for the Maintenance of Smooth Muscle Cell Identity as Revealed by Single-Cell Transcriptomics. Circulation. 2018 Nov 13;138(20):2274-2288. (IF=23.05)

7. Yuan X#, Zhang T#, Yao F, Liao Y, Liu F, Ren Z, Han L, Diao L, Li Y, Zhou B, He F, Wang L*. THO Complex-Dependent Posttranscriptional Control Contributes to Vascular Smooth Muscle Cell Fate Decision. Circ Res. 2018 Aug 17;123(5):538-549. (IF=15.86)

8. Li P#, Wang L#, Bennett BD, Wang J, Li J, Qin Y, Takaku M, Wade PA, Wong J, Hu G*. Rif1 Promotes a Repressive Chromatin Sstate to Safeguard Against Endogenous Retrovirus Activation. Nucleic Acids Res. 2017 Dec 15;45(22):12723-12738. (IF=12.17)

9. Wang L#, Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams CJ, Wade PA, Hu G*. INO80 Facilitates Pluripotency Gene Activation in Embryonic Stem Cell Self-renewal, Reprogramming, and Blastocyst Development. Cell Stem Cell. 2014 May 1;14(5):575-91. (IF=22.27, C100)

10. Wang L#, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G*. The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90. (IF=25.32)